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Anotace knihy

The human calcium sensing receptor (hCaR) is a§G-protein coupled receptor that responds to calcium§ions as its principal physiological agonist. L-amino§acids are allosteric activators of the cloned CaR§expressed in HEK293 cells but the physiological§significance of this effect has been uncertain. This§book provides evidence that L-amino acids are§physiologically relevant activators of endogenous§CaRs. Experiments reported in this book also§investigated the location of amino acid binding site§of the CaR. Chimeric receptors constructed by domain§shuffling between the human CaR and rat metabotropic§glutamate receptor type-1 (mGlu-1) were used to§localize the amino acid binding site of the CaR to§its N-terminal, bilobed, Venus Fly Trap domain.§Furthermore, the roles of putative amino acid binding§site residues in the Venus Fly Trap domain were§investigated using conservative and semi-conservative§mutations of the following residues: T145, S147,§T151, S169, S170, S171, Y218 and E297. Finally, a§novel activating mutation (E604K) in the cysteine§rich domain of the hCaR in an Australian family with§autosomal dominant hypocalcemia (ADH) was identified.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Biochemistry

• Plný název: L-Amino Acid Sensing by the Calcium Sensing Receptor
• Podnázev: Molecular and Functional Analysis
• Autor: Hee-chang Mun
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 196
• EAN: 9783639061925
• ISBN: 3639061926
• ID: 06815584
• Nakladatelství: VDM Verlag
• Hmotnost: 295 g
• Rozměry: 229 × 152 × 11 mm
• Datum vydání: 19. February 2009

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