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Více informací o knize Synthesis of Novel Heterocycles and Their Pharamacological Activity

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Anotace knihy

Antibiotics are one of our most important weapons to cover bacterial infections and improve human life . Infectious diseases are the leaders among the challenging drug targets because of the multi-drug resist antimicrobial pathogens and continuous rise in the emerging infections from known and unknown sources. Tyrosine kinases are orally active, small molecules that have a favorable safety profile and can be easily combined with other forms of chemotherapy or radiation therapy. The combination of two pharmacophores into a single molecule is an effective and commonly used direction in modern medicinal chemistry for the exploration of novel and highly active compounds. A variety of safe and effective antiinflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. The pharmacophoric structural features of the selective COX-2 inhibitors possess a central heterocyclic five member ring system bearing two vicinal aryl moieties, such as pyrazole (celecoxib), 2(5H) furanone (rofecoxib), and isoxazole (valdecoxib).

Parametry knihy

• Plný název: Synthesis of Novel Heterocycles and Their Pharamacological Activity
• Podnázev: Novel Heterocycles and its Pharmacological activity
• Autor: Dhananjay Mane, Laxmikant Pavase
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 220
• EAN: 9786139896486
• ID: 20258163
• Nakladatelství: LAP Lambert Academic Publishing
• Hmotnost: 346 g
• Rozměry: 220 × 150 × 13 mm
• Rok vydání: 2018

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