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Anotace knihy

In recent years, alongside the largely popularized advances in human genome editing and CRISPR-cas9-driven therapeutics, epigenomic editing has made strong strides, though a clear understanding is still forming in the field of the exact role that epigenetics play in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. Key questions for researchers embarking in this field include: Which of the hundreds of epigenomic marks and features are relevant, and which of those are likely to serve a role in regulating gene expression, cell behavior, and phenotypic outcomes? This volume is the first to provide a thorough, conceptual introduction to the field of epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Protocols, and applied case studies examine early disease targets and likely pathways of therapeutic significance, while also outlining common challenges in the field, and the addressing the range of bioethical questions that come with altering phenotypes. This book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research. Offers a full, conceptual and applied framework for implementing epigenomic editing in biological research and drug discovery Discusses fundamental theory, experimental design, and applied approaches alongside common research challenges and bioethical concerns Examines epigenomic editing’s potential role in modulation of developmental, neuropsychiatric, and immunological disorders, as well as viral infections and cancer

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Life sciences: general issues

• Plný název: Site Specific and Global Epigenomic Editing
• Podnázev: Principles and Applications
• Autor: Feng Zhou
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 704
• EAN: 9780128193983
• ID: 37371972
• Nakladatelství: Elsevier Books
• Rozměry: 235 × 191 mm
• Datum vydání: 01. August 2023

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