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Více informací o knize Regulation of the exchange activity of Dbl-family proteins

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Anotace knihy

Dbl-related oncoproteins are guanine nucleotide§exchange factors (GEFs) specific for Rho-family§GTPases and typically possess tandem Dbl (DH) and§pleckstrin homology (PH) domains that act in concert§to catalyze exchange. The exchange activities of§many Dbl-proteins are regulated by phosphorylation or§constitutively activated by truncations preceding§their DH domains. However, exact mechanisms of§regulation remain poorly understood. The current§literature regarding the activation and inhibition of§the exchange activity of the human Dbl-family§proteins is reviewed here, with a focus on general§mechanisms of regulation common to many of these§proteins.

Parametry knihy

• Plný název: Regulation of the exchange activity of Dbl-family proteins
• Podnázev: Auto-inhibition, intermolecular interactions and phosphorylation in the regulation of Dbl-family proteins
• Autor: Marielle Yohe
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 108
• EAN: 9783639161502
• ID: 06824578
• Nakladatelství: VDM Verlag Dr. Müller
• Hmotnost: 177 g
• Rozměry: 220 × 150 × 6 mm
• Rok vydání: 2009

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