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Více informací o knize Methionine Oxidation in Human Prion Protein

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• Anotace
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Anotace knihy

The aim of this thesis was to examine the pathological relevance of the oxidation state of methionine (Met) side chains in neurodegenerative disorders such as sporadic prion disease. First for better understanding the oxidative event, the effect and consequences of Met oxidation in the recombinant human cellular prion protein (rhPrPC23-231) were studied. Second the incorporation of stable Met analogs, norleucine and methoxinine, in rhPrPC23-231 mimicking the reduced and oxidized state of Met, respectively was performed. The results strongly indicate a correlation of the secondary structure conversion in rhPrPC with the oxidative state of the Met residues. In the future, this approach will certainly be useful for studying diseases, which arise from protein misfolding due to oxidative stress.

Parametry knihy

• Plný název: Methionine Oxidation in Human Prion Protein
• Podnázev: Design of Anti- and Pro-Aggregation Variants
• Autor: Christina Wolschner
• Jazyk: Němčina
• Vazba: Brožovaná
• Počet stran: 136
• EAN: 9783838109404
• ISBN: 3838109406
• ID: 07149058
• Nakladatelství: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Hmotnost: 209 g
• Rozměry: 229 × 152 × 9 mm
• Datum vydání: 17. July 2009

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