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Více informací o knize Genetic algorithm for haplotyping and block partitioning

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Anotace knihy

A new algorithm for performing simultaneous haplotype resolution and block partitioning is proposed. The algorithm is based on genetic algorithm approach and the parsimonious principle. The multiloculs LD measure (Normalized Entropy Difference) is used as a block identification criterion. The proposed algorithm incorporates missing data is a part of the model and allows blocks of arbitrary length. In addition, the algorithm provides scores for the block boundaries which represent measures of strength of the boundaries at specific positions. The results show that the proposed genetic algorithm provides the accuracy of haplotype decomposition within the range of the same indicators shown by the other algorithms. The proposed algorithm is also used in a new population clustering algorithm, which extracts from the given genotype sample two clusters with substantially different block structures and finds haplotype resolution and block partitioning for each cluster.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Life sciences: general issues

• Plný název: Genetic algorithm for haplotyping and block partitioning
• Autor: Nadezhda Sazonova
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 132
• EAN: 9783639237849
• ISBN: 3639237846
• ID: 06831469
• Nakladatelství: VDM Verlag
• Hmotnost: 204 g
• Rozměry: 229 × 152 × 8 mm
• Datum vydání: 05. March 2010

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