Mohlo by se vám také líbit

Více informací o knize Brimonidine base-loaded Solid Lipid Nanoparticles for Ocular Delivery

• Parametry knihy
• Anotace
• Oblíbené z jiného soudku

Nákupem získáte 101 bodů

Anotace knihy

Using glyceryl monostearate or Precirol® ATO 5 as solid lipid in 4% w/w concentration in addition to 0.05% w/w Poloxamer® 188, as an emulsifier were optimum for entrapping the hydrophobic Brimonidine base. The prepared solid lipid nanoparticles formulations showed uniform, nanosized particles below 500 nm, suitable for ophthalmic application, of good entrapment efficiency and accompanied by a sustained Brimonidine base release, compared to both Brimonidine(TM) eye drops and Brimonidine dispersion. Glyceryl monostearate solid lipid nanoparticles formulation showed good corneal permeation and localization of the solid lipid nanoparticles in the anterior ocular chamber, acting as a depot for sustained Brimonidine base release. A significant (P 0.05) lowering in intraocular pressure compared to Brimonidine(TM) eye drops and excellent ocular tolerance were determined. It was concluded that; solid lipid nanoparticles formulation is a promising approach for ocular delivery of Brimonidine base to improve its clinical effect.

Parametry knihy

• Plný název: Brimonidine base-loaded Solid Lipid Nanoparticles for Ocular Delivery
• Podnázev: In-vitro, In-vivo Evaluation
• Autor: Noha El-Salamouni
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 96
• EAN: 9783659912870
• ID: 13787639
• Nakladatelství: LAP Lambert Academic Publishing
• Hmotnost: 159 g
• Rozměry: 220 × 150 × 6 mm
• Rok vydání: 2016

Oblíbené z jiného soudku

---

---

---