Kód: 13728411
Huntington disease is a complex neurodegenerative disorder. Presently, it is being treated sympatomatically based on patient symptoms/ condition. Present work is an attempt of authors to share their observation that treatment with ... celý popis
Nákupem získáte 171 bodů
Huntington disease is a complex neurodegenerative disorder. Presently, it is being treated sympatomatically based on patient symptoms/ condition. Present work is an attempt of authors to share their observation that treatment with caffeine and dipyridamole displayed significant protection highlighting their neuroprotective efficacy in HD like conditions.This further confirmed that targeting adenosinergic system could be an important therapeutic strategy in the management of HD like symptoms. Further, it has been observed that treatment with rapamycin caused marked improvement in the QA induced behavioural (motor and memory) alteration, oxidative burden, mitochondrial dysfunction, neuroinflammation, apoptosis, neurotrophin levels highlighting role of autophagy in excitotoxic conditions.
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Osobní odběr Praha, Brno a 12903 dalších
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