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Více informací o knize Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones

• Parametry knihy
• Anotace
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Anotace knihy

Tuberculosis and Cancer are among the most§devastating and therapeutically challenging diseases.§The development of muti-drug resistance in TB causing§bacteria, Mycobacterium tuberculosis and cancerous§cells has prompted the search for effective novel§compounds. This book focuses on the synthesis and the§evaluation of different analogues of diospyrin, a§proven anti-TB and anti-cancer agent. A number of§novel binaphthoquinone and naphthoquinone-naphthalene§biaryl compounds were synthesized by using Suzuki§methodology.§Several analogues were evaluated for their biological§activity against fast growing bacteria viz., M.§smegmatis and M. aurum and against a clinical strain§of M. tuberculosis. Four novel quinones were also§evaluated for their ability to induce apoptosis in§three cancer cell lines viz., HeLa, MCF7, MG63 and§one normal cell line i.e. CHO by using APOpercentage,§DNA fragmentation and Cell cycle assays. This§preliminary investigation could provoke an interest§in scientific community to synthesize other§structurally modified quinonoids in order to develop§and establish them as potent drugs against§mycobacterium and cancer.

Parametry knihy

• Plný název: Synthesis and Evaluation of anti-TB and Pro-apoptotic Quinones
• Podnázev: The Synthesis and Evaluation of Potential anti-Mycobacterium tuberculosis and Pro-apoptotic Quinones
• Autor: Sunil Sagar
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 120
• EAN: 9783639076301
• ID: 06816875
• Nakladatelství: VDM Verlag Dr. Müller
• Hmotnost: 195 g
• Rozměry: 220 × 150 × 7 mm
• Rok vydání: 2009

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