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Více informací o knize Synthesis and biological testing of 1-adamantyl derivatives

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Anotace knihy

Several adamantane derivatives have long been known for diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti-inflammatory agents. adamantyl derivatives were recently reported to possess 11-HSD1 inhibitory activities. In addition, 1,2,4-triazole and 1,3,4-thiadiazole were reported to constitute the pharmacologically active moiety of several compounds. On these bases new series of 1-adamantyl derivatives, in which the adamantyl moiety was attached to 1,2,4-triazole, 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole or 1,3,4-thiadiazole nucleus, have been synthesized as potential bioactive agents All the synthesized compounds were tested for their in vitro growth inhibitory activity against a panel of standard strains of pathogenic microorganism including Gram-positive bacteria, Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. In addition, the acute anti-inflammatory activity of a representative compounds was determined in vivo following the carrageenan-induced paw oedema method in rats.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Other branches of medicine Pharmacology

• Plný název: Synthesis and biological testing of 1-adamantyl derivatives
• Autor: Dr Ihsan
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 176
• EAN: 9783639246704
• ISBN: 9783639246704
• ID: 08909103
• Nakladatelství: VDM Verlag
• Hmotnost: 263 g
• Rozměry: 152 × 229 × 10 mm
• Datum vydání: 01. April 2010

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