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Více informací o knize Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation

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The most widely accepted theory for the massive §depletion of CD4+ T cells in HIV-1 infection §involves depletion of non-infected cells through §immune activation. A specialized cell population, §the T regulatory cells (Tregs), exists to help limit §chronic inflammation by suppressing the immune §activation induced by infectious diseases. We used §an SIV/pigtailed macaque model of HIV-1 disease to §elucidate the role of Tregs in HIV-1-induced §depletion of CD4+ T cells in lymphoid tissue during §the acute phase of infection. From this model, we §learned that Tregs play a significant role in §controlling the apoptotic loss of CD4+ T cells §resulting from high levels of generalized immune §activation. Using assays developed in the macaque §model, we next studied the role of Tregs in elite §suppressors who are HIV-1-infected individuals that §maintain normal CD4+ T cell counts and control §viremia without therapy. The assays developed §in our laboratory should be especially useful to §the future studies of both virologists and §immunologists.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Medicine: general issues

• Plný název: Regulatory Mechanisms Controlling HIV-1 Induced Immune Activation
• Autor: Amanda Jewell Chase
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 76
• EAN: 9783639088892
• ISBN: 3639088891
• ID: 06818016
• Nakladatelství: VDM Verlag Dr. Mueller E.K.
• Hmotnost: 113 g
• Rozměry: 229 × 152 × 4 mm
• Datum vydání: 06. October 2008

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