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Více informací o knize Peptidomimetics in Organic and Medicinal Chemistry - The Art of Transforming Peptides in Drugs

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Anotace knihy

A peptidomimetic is a small protein-like chain designed to mimic a peptide with adjusted molecular properties such as enhanced stability or biological activity. It is a very powerful approach for the generation of small-molecule-based drugs as enzyme inhibitors or receptor ligands.§Peptidomimetics in Organic and Medicinal Chemistry outlines the concepts and synthetic strategies underlying the building of bioactive compounds of a peptidomimetic nature. Topics covered include the chemistry of unnatural amino acids, peptide- and scaffold-based peptidomimetics, amino acid-side chain isosteres, backbone isosteres, dipeptide isosteres, beta-turn peptidomimetics, proline-mimetics as turn inducers, cyclic scaffolds, amino acid surrogates, and scaffolds for combinatorial chemistry of peptidomimetics. Case studies in the hit-to-lead process, such as the development of integrin ligands and thrombin inhibitors, illustrate the successful application of peptidomimetics in drug discovery.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Other branches of medicine Pharmacology

• Plný název: Peptidomimetics in Organic and Medicinal Chemistry - The Art of Transforming Peptides in Drugs
• Autor: Antonio Guarna, Andrea Trabocchi
• Jazyk: Angličtina
• Vazba: Pevná
• Počet stran: 308
• EAN: 9781119950608
• ISBN: 1119950600
• ID: 02398981
• Nakladatelství: John Wiley and Sons Ltd
• Hmotnost: 646 g
• Rozměry: 176 × 252 × 20 mm
• Datum vydání: 12. March 2014

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