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Více informací o knize HCV Therapy and Baseline IL-8 Levels

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• Anotace
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Anotace knihy

HCV, a major cause of liver disease worldwide, is frequently resistant to the antiviral interferon- therapy, being the only approved treatment available. It has been investigated recently that interleukin-8 (IL-8) induced by HCV partially inhibit the IFN- therapy. Therefore we aimed to prospectively utilize the baseline IL-8 levels in the HCV infected serum and predict its role in sustained virological response (SVR) to IFN- + ribavirin therapy, in chronic HCV patients. Fifteen normal volunteers and 110 HCV patients were enrolled in this study. Their baseline IL-8 levels were determined by ELISA and pre & post-treatment viral loads were recorded using qPCR. Different response rates to the therapy were observed and significant correlation was found between baseline IL-8 level and response to IFN therapy (P0.01). Comparatively higher mean baseline IL-8 levels were observed in non-responders (2442.02 ±159.92 pg/ml), than the late (1009.31 ±45.31) and rapid (540.91 ±27.06 pg/ml) responders. Baseline IL-8 measurement should be used as a management tool before deciding the therapy, being involved in pathogenesis, persistence and resistance to antiviral therapy.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Microbiology (non-medical)

• Plný název: HCV Therapy and Baseline IL-8 Levels
• Podnázev: A Practical Approach
• Autor: Haji Akbar, Muhammad Idrees Khan, Khuram Shahzad
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 140
• EAN: 9783639336184
• ISBN: 3639336186
• ID: 06840265
• Nakladatelství: VDM Verlag
• Hmotnost: 213 g
• Rozměry: 229 × 152 × 8 mm
• Datum vydání: 04. March 2011

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