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Více informací o knize From Muscle to Brain

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Anotace knihy

The dystroglycans (DGs), and -DG, form the core of the dystrophin glycoprotein complex in the skeletal muscle as a transmembrane linkage between the cytoskeleton and the extracellular matrix. Disruption of this linkage leads to muscular dystrophy. DG is also implicated in synaptogenesis of the neuromuscular junction. In the central nervous system (CNS), however, roles of DG remain largely unknown. As a step toward revealing the function of DG in the CNS, affinity-purified rabbit antisera against -DG were raised and tested, which recognize only DG in brain extracts. Immunocytochemistry with the sera found in cultured rat hippocampal neurons DG is expressed in cell bodies, dendrites and axons and forms clusters at some dendritic spines and is colocalized with synaptophysin. Immunoaffinity purification revealed that -DG is associated with -DG in rat hippocampus, but the isoforms of dystrophin and utrophin are undetectable. In Coomassie-blue stained gels, in addition to -DG, a band of about 100 kD was also found. This band does not match any proteins known to interact with -DG and its identity and function could uncover a new role of DG complex in the CNS.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences

• Plný název: From Muscle to Brain
• Podnázev: A Study of Dystroglycan
• Autor: Yougen Zhan
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 112
• EAN: 9783639197259
• ISBN: 3639197259
• ID: 06827789
• Nakladatelství: VDM Verlag
• Hmotnost: 177 g
• Rozměry: 229 × 152 × 7 mm
• Datum vydání: 01. October 2009

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