Effect of antioxidants grafting on the hemocompatibility of HD / Nejlevnější knihy
Effect of antioxidants grafting on the hemocompatibility of HD

Kód: 06824356

Effect of antioxidants grafting on the hemocompatibility of HD

Autor Fu-Chen Kung

In this study, hollow fiber membrane (PAN,CA and §PSF) was hydrolyzed and grafted with antioxidants §such as conjugated linoleic acid (CLA)or heparin. §The effects of antioxidants grafting on the blood §coagulation, platelet aggre ... celý popis

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Anotace knihy

In this study, hollow fiber membrane (PAN,CA and §PSF) was hydrolyzed and grafted with antioxidants §such as conjugated linoleic acid (CLA)or heparin. §The effects of antioxidants grafting on the blood §coagulation, platelet aggregation, and oxidative §stress were evaluated using human blood. The §complete blood count (CBC) and coagulation time (CT) §was evaluated in vitro for the hemocompatibility. §Furthermore, the removal of bacterial endotoxin §(lipopolysaccharide, LPS) by antioxidant-bonding §membrane was measured with ELISA. In addition, the §production of reactive oxygen species (ROS) was §measured by chemiluminescence (CL) method to §evaluate the oxidative stress. §In vitro evaluation was carried out using mini-§hemodialyzer circulating with fresh porcine whole §blood to simulating kidney therapy. The dialysis §performance and hemocompatibility were estimated.§These results suggest that a antioxidant-grafting §membrane could offer protection for patients against §oxidative stress and would be helpful for reducing §the dosage of anticoagulant during hemodialysis.

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Zařazení knihy Knihy v angličtině Technology, engineering, agriculture Technology: general issues Engineering: general

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