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Anotace knihy

An important problem in computational biology is identifying short DNA sequences (mathematically, 'words') associated to a biological function. One approach consists in determining whether a particular word is simply random or is of statistical significance, for example, because of its frequency or location. This book introduces the mathematical and statistical ideas used in solving this so-called exceptional word problem. It begins with a detailed description of the principal models used in sequence analysis: Markovian models are central here and capture compositional information on the sequence being analysed. There follows an introduction to several statistical methods that are used for finding exceptional words with respect to the model used. The second half of the book is illustrated with numerous examples provided from the analysis of bacterial genomes, making this a practical guide for users facing a real situation and needing to make an adequate procedure choice.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences Life sciences: general issues

• Plný název: DNA, Words and Models
• Podnázev: Statistics of Exceptional Words
• Autor: S. RobinF. RodolpheS. Schbath
• Jazyk: Angličtina
• Vazba: Pevná
• Počet stran: 158
• EAN: 9780521847292
• ISBN: 052184729X
• ID: 02046802
• Nakladatelství: Cambridge University Press
• Hmotnost: 386 g
• Rozměry: 236 × 160 × 13 mm
• Datum vydání: 13. October 2005

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