Corticosteroids And Red Cell System / Nejlevnější knihy
Corticosteroids And Red Cell System

Kód: 06855822

Corticosteroids And Red Cell System

Autor Kailash Agarwal

Corticosteroids have been associated with hematological changes i. e. erythropoiesis, neutrophilia, lymphocyte and eosinopenia in endocrinal disorders and hematological diseases i.e. hypoplastic marrow stimulation; immune thromboc ... celý popis

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Anotace knihy

Corticosteroids have been associated with hematological changes i. e. erythropoiesis, neutrophilia, lymphocyte and eosinopenia in endocrinal disorders and hematological diseases i.e. hypoplastic marrow stimulation; immune thrombocytopenia- increase in platelet count and hemoglobin, and in acute lymphoblastic leukemia-remission. The present study conducted in bronchial asthma associated with eosinophilia, in spite of being on long term corticosteroid therapy showed: a) erythropoiesis- about 10% rise in hemoglobin, hematocrit and red cell count. This rise was observed with a dose of hydrocortisone even below 0.49mg/kg per day, with maximum effect on dosages from 0.50-0.99 mg/kg per day and within 3 months of therapy. No further increase was observed with dosages of 1.0-1.99 mg/kg per day. b) On discontinuation of corticosteroid therapy the hemoglobin concentration returned to normal after a period varying from 2 weeks to 4 months. c) The erythropoiesis was further confirmed by demonstrating around 10% increase in total hemoglobin and total red cell volume by Cr51 technique. The blood volume did not change; there was reduction in plasma volume in children receiving corticoste.

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