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Více informací o knize Bioisosteres in Medicinal Chemistry

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Anotace knihy

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.§As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development.§The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered,§while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part§covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of§protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed.§With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.

Parametry knihy

Zařazení knihy Knihy v angličtině Technology, engineering, agriculture Industrial chemistry & manufacturing technologies Industrial chemistry

• Plný název: Bioisosteres in Medicinal Chemistry
• Autor: Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
• Jazyk: Angličtina
• Vazba: Pevná
• Počet stran: 256
• EAN: 9783527330157
• ISBN: 3527330151
• ID: 01551080
• Nakladatelství: Wiley-VCH Verlag GmbH
• Hmotnost: 632 g
• Rozměry: 248 × 173 × 16 mm
• Datum vydání: 22. August 2012

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