Mohlo by se vám také líbit

Více informací o knize Nuclear Receptors: From Structure to the Clinic

• Parametry knihy
• Anotace
• Oblíbené z jiného soudku

Nákupem získáte 331 bodů

Anotace knihy

Nuclear Receptors focuses on the structural analysis of nuclear receptors from the initial work using isolated protein domains to the more recent exciting developments investigating the conformational shape of full-length receptor complexes. The book also reviews the structure of key nuclear receptor co-regulatory proteins. It brings together, for the first time, a comprehensive review of nuclear receptor structure and the importance of receptor conformation underpinning allosteric regulation by different ligands (hormone, drugs, DNA response elements, protein-protein interactions) and receptor activity.§§The nuclear receptor superfamily, including receptors for steroid hormones and non-steroid ligands, are pivotal to normal physiology, regulating processes as diverse as reproduction, metabolism, the immune system and brain development. The first members of the family were cloned over 25 years ago, which heralded in the idea of a superfamily of intracellular receptor proteins that bound small molecule ligands: classical steroid hormones, vitamins, fatty acids and other products of metabolism. These signals are then transmitted through multiprotein receptor-DNA complexes, leading to the regulation of target genes, often in a cell-selective manner. The cloning of the receptor cDNAs also ushered in an era of unparalleled analysis of the mechanisms of action of these ligand-activated transcription factors.§

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Pre-clinical medicine: basic sciences Physiology

• Plný název: Nuclear Receptors: From Structure to the Clinic
• Autor: Iain J. McEwan, Raj Kumar
• Jazyk: Angličtina
• Vazba: Pevná
• Počet stran: 236
• EAN: 9783319187280
• ISBN: 3319187287
• ID: 09271951
• Nakladatelství: Springer International Publishing AG
• Hmotnost: 633 g
• Rozměry: 235 × 155 × 243 mm
• Datum vydání: 20. August 2015

Oblíbené z jiného soudku

---

---

---