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Více informací o knize Transdermal Delivery of Ethosomal Aceclofenac

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Anotace knihy

The aim of the work is to evaluate the transdermal potential of novel vesicular carrier, ethosomes, bearing aceclofenac, Non-steroidal anti-inflammatory drugs having limited transdermal permeation. Aceclofenac loaded ethosomal carriers were prepared, optimized and characterized for vesicular shape and surface morphology, scanning electronic microscopy, vesicular size, entrapment efficiency, stability, in- vitro release study.The formulation having 3% phospholipids content and 40% ethanol showing the grater entrapment and optimal average vesicle size of formulation was determine by Malvern Zetamaster & found 0.696µm and zeta potential of formulation was -6.74 mV. The vesicular suspension was kept in sealed vials (10ml) at 4 ± 2şC and at room temperature for 45 days no change is shown in the entrapment efficiency. The optimized ethosomal formulation showed transdermal flux (226.1 µg/cm˛/hr) for ethanolic drug solution which is grater then that of isopropyl alcohol solution (159.0 µg/cm˛/hr). The result advocates the potential of ethosome formulation to treat rheumatic disease where facilitated penetration of the drug into muscle and synovial fluid is desirable.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Other branches of medicine Pharmacology

• Plný název: Transdermal Delivery of Ethosomal Aceclofenac
• Autor: Vivek Dave, Dhirendra Kumar, Sarvesh Paliwal
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 104
• EAN: 9783639257137
• ISBN: 3639257138
• ID: 06833133
• Nakladatelství: VDM Verlag
• Hmotnost: 163 g
• Rozměry: 229 × 152 × 6 mm
• Datum vydání: 26. May 2010

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