Mohlo by se vám také líbit

Více informací o knize Sulfonamide Based Polymeric Systems for Cancer Tumors

• Parametry knihy
• Anotace
• Oblíbené z jiného soudku

Nákupem získáte 208 bodů

Anotace knihy

This monograph focuses on the design and study of §innovative polymeric drug delivery systems for §acidic solid cancer tumors. A sulfonamide-based pH-§sensitive polymer was developed to mask conventional §delivery systems such as gene carrier and polymeric §micelles, during systemic circulation and unmask §them at the acidic tumor. First a pH-sensitive §polymer (PSD-b-PEG) was evaluated in a gene delivery §model. Plasmid DNA was complexed with PEI, this §further complexed with PSD-b-PEG to construct a §nanoparticle. The nanoparticles showed low §cytotoxicity (20%) and low transfection at pH 7.4 §due to shielding of PEI by PSD-b-PEG and high §cytotoxicity (80%) and high transfection at pH 6.6, §indicating deshielding. This indicated PSD-b-PEG''s §ability to discern the difference in pH between §normal and tumor tissue. Next DOX loaded micelles §using PSD-b-PEG were designed. Evaluation of the DOX §loaded PMCs in tumor bearing mice showed tumor §regression up to 33 days compared to 12 days for §regular DOX micelles.A new pH sensitive polymer, §PCBS-b-PEG, was developed next. This polymer was not §only able to mimic the PSD-b-PEG but was §biodegradable as well.

Parametry knihy

Zařazení knihy Knihy v angličtině Technology, engineering, agriculture Technology: general issues

• Plný název: Sulfonamide Based Polymeric Systems for Cancer Tumors
• Podnázev: Design and study of sulfonamide polymer based pH sensitive micelles and polyplexes for targeting acidic solid tumors
• Autor: Vijay Sethuraman
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 164
• EAN: 9783639136203
• ISBN: 3639136209
• ID: 06822298
• Nakladatelství: VDM Verlag
• Hmotnost: 249 g
• Rozměry: 229 × 152 × 10 mm
• Datum vydání: 25. March 2009

Oblíbené z jiného soudku

---

---

---