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Více informací o knize O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter

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Anotace knihy

The AIDS pandemic is caused by the Human Immunodeficiency Virus Type-1 (HIV-1). To date, there is neither a vaccine against HIV-1, nor a cure for AIDS available. HIV-1 gene expression and replication is regulated by the binding of cellular transcription factors to specific regulatory sites in the 5 -long terminal repeat (LTR) promoter. In this study it is demonstrated that the cell s glucose metabolism represses the replication of HIV- 1. This is based on the enzyme O-GlcNAc transferase (OGT), which is activated by increased glucose concentration and modifies proteins posttranslationally with the monosaccharide O- GlcNAc. OGT blocks the cellular transcription factor Sp1, which is essential for the replication of HIV-1 and thereby represses virus propagation. Hence, the establishment of a metabolic treatment might supplement the repertoire of antiretroviral therapies against AIDS.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Biology, life sciences

• Plný název: O-linked N-Acetylglucosaminylation of Sp1 Inhibits the HIV-1 Promoter
• Autor: Ramona Jochmann
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 120
• EAN: 9783838111445
• ISBN: 3838111443
• ID: 06976057
• Nakladatelství: Sudwestdeutscher Verlag Fur Hochschulschriften AG
• Hmotnost: 186 g
• Rozměry: 229 × 152 × 8 mm
• Datum vydání: 12. October 2009

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