Mohlo by se vám také líbit

Více informací o knize Method development and validation of anti-histaminic drug in plasma

• Parametry knihy
• Anotace
• Oblíbené z jiného soudku

Nákupem získáte 138 bodů

Anotace knihy

A selective, rapid and sensitive reverse phase ultra- performance liquid chromatography method was developed for the quantitative determination of fexofenadine in human plasma. With carbamazepine as internal standard, sample pretreatment involved a one-step extraction with ethyl acetate from 980µl plasma. The sample was analyzed using 10mM KH2PO4 buffer pH 2.5 and acetonitrile (70:30 v/v) as mobile phase. Chromatographic separation was achieved on an ACQUITY UPLC BEH (C-18) column using isocratic elution. The peak was detected using UV-PDA detector set at 210 nm and the total time for chromatographic separation was 10 min. Linear calibration curves were obtained in the concentration range of 30.09-1805.39 ng/ml with a lower limit of quantification of 30.09 ng/ml. The inter and intra- day precision (RSD) values were below 15% and accuracy (RE) was from 1.55 to 5.51 % at all QC levels. Developed method was found to be accurate, precise, selective and rapid for estimation of fexofenadine in plasma and can be used for pharmacokinetic and bioequivalence studies.

Parametry knihy

Zařazení knihy Knihy v angličtině Mathematics & science Chemistry

• Plný název: Method development and validation of anti-histaminic drug in plasma
• Autor: Mr.Maulikkumar Amin, Deepti Jain, M. M. Patel
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 76
• EAN: 9783639377828
• ISBN: 3639377826
• ID: 06844330
• Nakladatelství: VDM Verlag
• Hmotnost: 122 g
• Rozměry: 229 × 152 × 5 mm
• Datum vydání: 18. August 2011

Oblíbené z jiného soudku

---

---

---