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Více informací o knize Glial cells in the enteric nervous system

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Anotace knihy

Enteric glial cell (EGC) markers were thoroughly§characterized in the human enteric nervous system§(ENS) and EGC numbers were compared in man and guinea§pig. As a result, the Sox8/9/10 antibody was shown to§be an excellent investigative tool to assess EGC in§the ENS and the glia index was identified as the most§robust quantitative descriptor within a species.§Subsequently, this Sox8/9/10 was used in Crohn s§disease specimens to quantify enteric glia. In a§parallel approach, interactions of EGC and the§intestinal epithelial barrier were analyzed. Results§from these experiments indicate a protective effect§of EGCs on the intestinal epithelial barrier in§intestinal inflammation. The observed expression of§GDNF, NGF, NT-3 and their receptors by EGC points to§promising targets for further research to elucidate§the exact nature of glial-derived mucosa-protective§factors.

Parametry knihy

Zařazení knihy Knihy v němčině Naturwissenschaften, Medizin, Informatik, Technik Biologie

• Plný název: Glial cells in the enteric nervous system
• Podnázev: Plasticity of glial cells in the enteric nervous system during intestinal inflammation
• Autor: Sebastian Hoff
• Jazyk: Němčina
• Vazba: Brožovaná
• Počet stran: 148
• EAN: 9783838107257
• ID: 06961803
• Nakladatelství: Südwestdeutscher Verlag für Hochschulschriften
• Hmotnost: 213 g
• Rozměry: 220 × 150 × 8 mm
• Rok vydání: 2009

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