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Anotace knihy

Mental disorders are complex diseases with strong §genetic components. Clinical studies have §demonstrated the associations of genetic variants in §candidate genes with susceptibility to several §common mental diseases such as schizophrenia, §depression, bipolar disorders, and drug addiction, §but little was known about the underlying §mechanisms. Single nucleotide polymorphisms (SNPs), §naturally occurring nucleotide substitutions in DNA §sequence, are the most common genetic variants, §which can modulate gene expression at the level of §mRNA and protein by affecting transcription, mRNA §processing, pre-mature RNA splicing, mRNA stability, §or translation. My studies examined the extent and §nature of SNPs in mu opioid receptor and D2 dopamine §receptor genes, which provided a foundation for §clinical association studies by clarifying the §functional relevance of these SNPs with §susceptibility to mental disorders. My work should §be especially useful to professionals in §neuroscience, psychiatry, and genetics or anybody §who are interested in understanding the genetic §mechanisms of mental disorders.

Parametry knihy

• Plný název: FUNCTIONAL GENETIC VARIANTS AND MENTAL DISORDERS
• Podnázev: Single nucleotide polymorphisms and their effects in genes involved in mental disorders
• Autor: Ying Zhang
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 140
• EAN: 9783639166453
• ID: 06825019
• Nakladatelství: VDM Verlag Dr. Müller
• Hmotnost: 225 g
• Rozměry: 220 × 150 × 8 mm
• Rok vydání: 2009

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