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Více informací o knize Formulation and Development of Bilayer Floating Tablets of Nifedipine

• Parametry knihy
• Anotace
• Oblíbené z jiného soudku

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Anotace knihy

The aim of the present research work was to develop and formulate a bilayer floating sustained release tablet of Nifedipine. Nifedipine is an antihypertensive agent. Surface solid dispersion of Nifedipine was prepared by solvent evaporation method with different super disintegrants as a polymer for improvement of solubility resulting in improved bioavailability. Bilayer consists of two layers, immediate-release layer, and second sustained release layer, compressed in the single unit dosage form. The immediate-release layer contains surface solid dispersion of Nifedipine. The floating sustained release layer also contains surface solid dispersion of Nifedipine, HPMC K100M & HPMC K15M as sustained release polymer. The floating properties of the tablets were achieved by the use of sodium bicarbonate & citric acid which generate the gas upon contact with gastric fluid. The immediate-release layer releases the drug immediately and starts the onset of action and the floating sustained release layer floats on gastric fluid for upto12 hours and releases the drug in a sustained manner, subsequently, it prolongs the duration of action.

Parametry knihy

• Plný název: Formulation and Development of Bilayer Floating Tablets of Nifedipine
• Autor: Sharma Dinesh Kumar Sharma, Behera Amulyaratna Behera, Pattnaik Gurudutta Pattnaik
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 108
• EAN: 9786203410877
• ISBN: 620341087X
• ID: 36229265
• Nakladatelství: LAP Lambert Academic Publishing
• Hmotnost: 174 g
• Rozměry: 152 × 227 × 10 mm
• Datum vydání: 15. February 2021

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