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Více informací o knize Bovine Trophoblast Non-classical MHC Class I Proteins

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Anotace knihy

Extremely polymorphic and ubiquitously expressed classical MHC-I (MHC-Ia) proteins, which present the foreign antigenic peptides to CD8+ T lymphocytes, are involved in acceptance or rejection of tissue grafts based on the degree of similarity of these proteins among the cells of donor and recipient. Discovery of non-classical MHC-I proteins such as Human Leukocyte Antigen-G (HLA-G) in humans and Qa-2 in mice, led to a new paradigm of immune tolerance to fetus. Class-Ib proteins are important glycoproteins which are important modulators of maternal immune system during pregnancy. During third trimester, bovine fetal trophoblast cells express both MHC-Ia and MHC-Ib proteins, which suggests that these proteins play a role in separation of the fetal placenta during parturition. The MHC-Ib proteins expressed during third trimester are bovine leukocyte antigen (BoLA) NC1 00401, NC1 00501, NC2 00102, NC3 00101 and NC4 00201 proteins.N 01701, N 01802, NC1 00501, NC3 00101 and NC4 00201 proteins showed the cell-surface expression as identified with transfection assays performed in murine P815 and human K562 cells.

Parametry knihy

• Plný název: Bovine Trophoblast Non-classical MHC Class I Proteins
• Autor: Parveen Parasar
• Jazyk: Angličtina
• Vazba: Brožovaná
• Počet stran: 152
• EAN: 9783659915147
• ID: 14115237
• Nakladatelství: LAP Lambert Academic Publishing
• Hmotnost: 243 g
• Rozměry: 220 × 150 × 10 mm
• Rok vydání: 2016

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