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Více informací o knize Affinity And Efficacy: The Components Of Drug-receptor Interactions

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• Anotace
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Anotace knihy

The interaction of a drug with a receptor encodes a vector of information having components of affinity and efficacy. How this information is translated into a response depends on the unique cells, tissue, organ or system in which the receptor resides. This book describes how to analyze various responses to estimate the affinity and efficacy components of the initial drug-receptor interaction. More specifically, it describes how to measure the affinity and efficacy of drugs through the analysis of single receptor activity, the activation state of a population of receptors, and responses downstream from receptor activation. More light is shed on ligand-gated ion channels and G protein-coupled receptors in this book. The topics discussed include radio ligand binding, estimation of agonist affinity and efficacy, competitive antagonism, inverse agonism, allosteric agonists and modulators, ligand-directed signaling, modulation of pathway selectivity, and the analysis of the loss of function in tissues from receptor knockout mice. The natural history and structure of ligand-gated ion channels, G proteins, and G protein-coupled receptors are also discussed.

Parametry knihy

Zařazení knihy Knihy v angličtině Medicine Other branches of medicine Pharmacology

• Plný název: Affinity And Efficacy: The Components Of Drug-receptor Interactions
• Autor: Frederick J. Ehlert
• Jazyk: Angličtina
• Vazba: Pevná
• Počet stran: 752
• EAN: 9789814322560
• ISBN: 9814322563
• ID: 05070241
• Nakladatelství: World Scientific Publishing Co Pte Ltd
• Hmotnost: 1332 g
• Rozměry: 237 × 161 × 37 mm
• Datum vydání: 30. December 2014

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